The Use of Umbilical Stem Cells

Author(s): Peter Cassar, Renald Blundell

ABSTRACT
The use of umbilical stem cells in tissue engineering is gaining in popularity. Some of the various uses of these umbilical stem cells are highlighted in this review, focusing mainly on their cartilage, bone and neuronal differentiating abilities. The review will also shed light on the application of these abilities in human clinical trials to repair, protect and treat diseases, e.g. neurodegenerative diseases such as Alzheimer’s and cerebral palsy. A side by side comparison with bone marrow mesenchymal stem cells (current gold standard for tissue engineering) will give a better idea of the viability and efficiency of umbilical stem cell use.

Diagrammatic representation of cord cross-section and differentiation schematic diagram of HUCMSCs. This figure provides a simple diagrammatic representation of the umbilical cord with its two arteries and vein separated by an intervascular area which is immediately surrounded by a perivascular area and subamniotic later after that. As listed above these mesenchymal stromal cells are capable in differentiating into many different cells types and tissues. These stem cells’ vast differentiating ability coupled with their natural abundance leads to them being a very reasonable and efficient source for tissue engineering [2].
Diagrammatic representation of cord cross-section and differentiation schematic diagram of HUCMSCs. This
figure provides a simple diagrammatic representation of the umbilical cord with its two arteries and vein separated by an
intervascular area which is immediately surrounded by a perivascular area and subamniotic later after that. As listed above
these mesenchymal stromal cells are capable in differentiating into many different cells types and tissues. These stem cells’
vast differentiating ability coupled with their natural abundance leads to them being a very reasonable and efficient source
for tissue engineering [2].

Source:

Journal: Open Journal of Pathology
DOI: 10.4236/ojpathology.2016.61007 (PDF)
Paper Id: 63163 (metadata)

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