A Concept for a Novel Test for Chemical Parity

Authors: Heinz Langhals, Oswald Krotz Affiliation

ABSTRACT
Deviations from chemical parity (PV) were evaluated with the search for very small enantiomeric excesses in a racemate prepared from non chiral materials and were detected by means of the circular dichroism (CD). Thus, intensely light-absorbing perylenebiscarboximides were attached to axially chiral biphenyls for the amplification of CD effects by exciton interactions of the adjacent chromophores. A rapidly racemising system was applied for the exclusion of artifacts and compared with an analogous with locked chirally. A very slight enantiomeric excess was detected for the (M) enantiomer. Application of the method for other systems was suggested and relations to natural products discussed.

Source:

Journal: Green and Sustainable Chemistry
DOI: gsc.2018.84021(PDF)
Paper Id: 88119 (metadata)

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