Research Progress on Post-Traumatic Stress Disorder and Its Animal Model

Authors: Juncheng Guo, Yijun Yang, Xiang Li, Xiangling Jiang, Min Guo, Zhuo Liu,
Ping Huang, Jianhong Pan

ABSTRACT
Posttraumatic stress disorder (PTSD) is to a persistently severe mental disorder which is caused by individual exposure to some unusual threatening or catastrophic stressful events. Its essential clinical manifestations refer to repeated playback of traumatic experience, durative avoidance of related clues, mental numbness or affection paralysis, and persistent increase of vigilance level. At present, the pathogenesis of PTSD has not been fully elucidated, and the clinical therapeutic effect has not been ideal. Generally, the classical animal model of PTSD is mouse; the domestic and international researches in the animal model of PTSD in recent years remain active, which are summarized as follows.

Source:

Journal: Journal of Behavioral and Brain Science
DOI: 10.4236/jbbs.2019.94015(PDF)
Paper Id: 91788 (metadata)

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